|
KMID : 0376119920190010047
|
|
Medical Journal of the Red Cross Hospital
1992 Volume.19 No. 1 p.47 ~ p.60
|
|
|
A Correlative Study of Mitotic Figures, Ag-NORs and Flow Cytometry on the Proliferative Activity of the Non-Hodgkin's Lymphomas
|
|
|
|
|
Abstract
|
|
|
In non-Hodgkin's lymphomas, it has been well known that the prognosis of the disease depends on the clinical stage and therapeutic modality as the histologic grade. Histologic assessment of proliferating activity is important in grading and
classification of the non-Hodgkin's lymphomas.
To evaluate the relationship between conventional method(counting the mitoses), argyrophilic method(Ag-NORs) and attractive, but expensive and complicate method(Flow cytometry), the forty cases of non-Hodgkin's lymphomas, which had been routinely
processed and immunophenotypically classified, were studied. The numbers of the mitoses and Ag-NORs were counted in all 40 and in thirty-one cases among them DNA ploidy and cell cyclic study were done.
@ES The results were summarized as follows:
@EN 1) The mean numbers of mitoses and Ag-NORs were significantly different between low and intermediate grades, low and high grades, and intermediate and high grade of non-Hodgkin's lymphomas, However, there were no significant differences
between
each
histologic grades in the results of cell cyclic study using flow cytometry.
2) Between T and B cell lymphomas, there were no significant differences of the mean numbers of mitoses and Ag-NORs as well as the results of cell cyclic study using flow cytometry.
3) There was a positive correlation between the mean numbers of mitoses and Ag-NORs. However, no correlation was found between the proportion of the cells in each cells cycle and the mean numbers of mitoses as well as the mean of Ag-NORs
numbers.
4) Among 31 non-Hodgkin's lymphomas, in which flow cytometric analysis was done, 20 cases showed aneuploidy pattern of DNA. However, there was no difference in the incidence of aneuploidy between each histologic grades as well as functional
classes.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|